| 释义 |
phenindione Pharm.|fɛnɪnˈdaɪəʊn|
[f. phen- + indo-2 + -dione.]
A white crystalline solid, 2-phenylindan-1,3-dione, C15H10O2, which is a vitamin K analogue used as an anticoagulant, esp. in the treatment of thrombosis.
1955Proc. Soc. Exper. Biol. & Med. LXXXIX. 81/1 In an investigation of the effect of phenindione (PID) on the coagulation mechanism.., it was discovered that patients who had received this anticoagulant for more than about 30 days developed a distinctly prolonged glass clotting time. 1962Lancet 13 Jan. 104/2 Treatment with heparin and phenindione was begun, but after six hours the patient suddenly became unconscious and pulseless, though slow voluntary respirations persisted. 1974R. H. Hammer in W. O. Foye Princ. Med. Chem. xviii. 409/1 Phenindione is the most commonly used 1,3-indandione anticoagulant... The chief disadvantage of phenindione is its toxic side effects. |
