| 释义 |
ticlopidine, n. Pharmacol.
Brit. |tʌɪˈkləʊpɪdiːn|, U.S. |ˌtaɪˈkloʊpədin|
[‹ ti- (representing thio- comb. form) + clo- (representing chloro- comb. form2) + -pidine (representing pyridine n.), components of the molecular structure.]
A drug that inhibits the aggregation of blood platelets (now largely superseded by clopidogrel).
Chemical name: 5-[(2-chlorophenyl)methyl]-4,5,6,7-tetrahydrothieno[3,2-c]pyridine, C14H14ClNS.
1975J. J. Thebault et al. in Clin. Pharmacol. & Therapeutics 18 485/1 Ticlopidine..has been shown to be a potent platelet aggregation inhibitor. 1989Lancet 3 June 1215/1 This study provides evidence of a beneficial effect of ticlopidine in both men and women with a recent thromboembolic stroke. 2002Jrnl. Kentucky Med. Assoc. 100184 The thienopyridines, ticlopidine and clopidogrel, are useful alternatives for secondary stroke prevention in patients who do not respond to or cannot take aspirin. |
