| 释义 |
dicoumarin Chem.|daɪˈkuːmərɪn|
[ad. G. dicumarin (R. Fittig 1885, in Ber. d. Deut. Chem. Ges. XVIII. 2525), f. di-2 + coumarin.]
Orig., any compound with a structure based on two coumarin molecules joined together; now spec. the compound 3,3′-methylenebis-(4-hydroxycoumarin), C19H12 O6, a white powder first isolated from spoiled sweet clover as the cause of hæmorrhage in sweet clover poisoning of cattle and later prepared synthetically and used as an anti-coagulant.
1886Jrnl. Chem. Soc. L. 47 Salicylaldehyde and succinic aldehyde yield a dicoumarin..very similar in chemical behaviour to coumarin. 1941Jrnl. Biol. Chem. CXXXVIII. 526 The hemorrhagic agent..present in improperly cured hay made from the common sweet clovers..is the dicoumarin, 3,3′-methylenebis (4-hydroxycoumarin). 1943Acta Physiol. Scand. VI. 28 The author has presented data on the prothrombin depressing effect in animals and man of a dicoumarin..first isolated from moulded sweet clover hay. 1947tr. Schmidt's Textbk. Org. Chem. (ed. 5) ii. xi. 475 The clinical value of dicoumarin is enhanced by its lasting effect and the fact that it can be taken orally. 1965[see anticoagulant a. and n.]. |
